The 2021 Mercedes-Benz E 350 has 12 NHTSA recall campaigns affecting an estimated 2,172,106 vehicles. Recall repairs are always free at any authorized dealer. Owners have filed 19 complaints with NHTSA, most often about the electrical system. Last updated July 5, 2026.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.
Consequence
A loss of drive power can increase the risk of a crash.
Remedy
Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2017-2022 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, AMG GT-Class, C-Class, E-Class, S-Class, SL-Class, GLC-Class, CLS-Class, GLB-Class, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. An error…
Consequence
A disabled eCall system would prevent a vehicle occupant from contacting the emergency services call center in an emergency, potentially delaying emergency responders and increasing the risk of injury.
Remedy
The communication module software will be updated through an Over-the-Air (OTA) update or by a dealer, free of charge. Owner notification letters were mailed July 8, 2022. Owner notification letters will be mailed in phases, on July 8, 2022, May 17, 2024, July 29, 2024, and September 27, 2024. Owners may contact…
BACK OVER PREVENTION22V2320002022-04-08126,443 affected
Defect
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2018-2021 CLA-Class, GLE/GLS-Class, A-Class, C-Class, E-Class, E-Class Coupe/Convertible, GLA/GLB-Class, GLC-Class, and CLS-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The rearview camera may not display the rearview…
Consequence
An inoperable rearview camera display reduces the driver's rear view, increasing the risk of a crash.
Remedy
Dealers will update the rearview camera software, free of charge. Owner notification letters were mailed July 15, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022060007.
STEERING22V1890002022-03-258,396 affected
Defect
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel. Due to a software error in the hand detection control unit, the hands-off detection might not detect when the…
Consequence
Deactivated hands-off detection will prevent DISTRONIC system features from functioning, including warnings to grab the steering wheel and calling first responders as part of the Active Emergency Stop Assist, which can increase the risk of a crash or injury.
Remedy
Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040010.
AIR BAGS21V5270002021-07-12542 affected
Defect
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 CLS450, AMG E53, AMG CLS53, E350, E450, AMG GT43, AMG GT53, 2020 S450, S560, G550, AMG GLC63, 2020-2021 GLC300, and AMG G63 vehicles. The side crash sensor connectors may come loose, which could delay the activation of air bags and seatbelts during a side…
Consequence
Air bags and seatbelts that don't function as intended can increase the risk of injury during a crash.
Remedy
Dealers will inspect and replace as necessary, the side impact crash sensors, free of charge. Owner notification letters were mailed on September 3, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021070032/33.
SEAT BELTS21V4830002021-06-254,917 affected
Defect
Mercedes-Benz, LLC (MBUSA) is recalling certain 2021 G550, AMG G63, E350, E450, AMG CLS53, AMG E53, AMG GT43, AMG GT53, AMG GT63, 2021-2022 CLS450, and AMG E63 vehicles. The rear seat belt automatic locking retractors may deactivate early, which can prevent the child restraint system from securing properly. As…
Consequence
An unsecured child restraint system can increase the risk of injury during a crash.
Remedy
Dealers will inspect, and replace as necessary, the rear seat belt assemblies, free of charge. Owners notified of the voluntary recall campaign by an interim letter on August 13, 2021. A final letter was mailed on September 24, 2021. Owners may contact MBUSA customer service at 1-800-367-6372.
BACK OVER PREVENTION21V3540002021-05-14343,191 affected
Defect
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2021 CLA-Class, GLE/GLS-Class, A-Class, E-Class, E-Class Coupe and Convertible, GLA/GLB-Class, GLC-Class, CLS-Class, and AMG GT-Class 4-door Coupe vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The MBUX multimedia system…
Consequence
A backup camera that displays a blank image reduces the driver's rear view, increasing the risk of a crash or injury.
Remedy
The multimedia system software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. Owner notification letters were mailed beginning June 28, 2021. Owners may contact MBUSA customer service at 1-800-367-6373. MBUSA's number for this recall is 2021050012.
BACK OVER PREVENTION21V2280002021-04-016 affected
Defect
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 E350, E450, E450 Wagon, and AMG E63 vehicles. The parking control unit may fail to display the rearview camera image and cause the parking sensors to misidentify or fail to detect objects.
Consequence
An inoperative rearview camera display and/or parking sensors can reduce the driver's view and awareness of what is behind the vehicle, increasing the risk of a crash.
Remedy
All affected vehicles are still within MBUSA's control. MBUSA will replace the parking control unit, free of charge. The recall began April 8, 2021. Owner may contact MBUSA customer service at 1-800-367-6372.
SEAT BELTS21V2300002021-04-018,634 affected
Defect
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 C-Class, E-Class, E-Class Coupe and Convertible, GLC, CLS, AMG GT 4-door Coupe and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. A faulty electrical contact within the seat position switch may prevent the driver…
Consequence
Air bags and seat belts that do not perform properly in a crash can increase the risk of injury.
Remedy
MBUSA will notify owners, and dealers will replace the seat position switches, free of charge. Owner letters were mailed May 21, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021040016.
SEATS21V2160002021-03-26109 affected
Defect
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 E350, E450, E450 Wagon, E63S AMG, 2020 E63S AMG Wagon, and 2020-2021 E53 AMG vehicles. The passenger seat limiter may allow the seat to be positioned too close to the air bag.
Consequence
A seat too close to the air bag increases the risk of injury in the event of a crash necessitating the deployment of the frontal passenger air bag.
Remedy
MBUSA will notify owners, and dealers will recalibrate the passenger seat limiter, free of charge. The recall began April 29, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021040002.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2016 - 2021 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, GT-Class, C-Class, E-Class, S-Class, CLS-Class, SL-Class, B-Class, GLB-Class, GLC-Class, and G-Class vehicles. Please refer to the Part 573 report for specific vehicle model details. The…
Consequence
Failure of the eCall system may result in emergency responders being dispatched to the wrong location, increasing the risk of injury following a crash.
Remedy
MBUSA will notify owners, and the communication module software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. The recall began March 12, 2021. Owners may contact MBUSA customer service at 1-877-762-8267. MBUSA's number for this recall is 2021020025.
SEATS20V6730002020-10-301,337 affected
Defect
Mercedes-Benz USA, LLC. (MBUSA) is recalling certain 2021 E350 and E450, 2019-2021 AMG E53 and 2020-2021 AMG E63 vehicles. The front passenger seat may be missing the mechanical seat adjustment range limit stop, allowing the seat to move outside of the acceptable range in relation to the air bag.
Consequence
If the front passenger seat is adjusted beyond the acceptable range in relation to the air bag, there could be an increased risk of injury in the event of a crash with air bag deployment.
Remedy
MBUSA will notify owners, and dealers will inspect for the mechanical seat adjustment range limitation for the front passenger seat and install it if necessary, free of charge. The recall began December 18, 2020. Owners may contact MBUSA customer service at 1-800-368-6372. MBUSA's number for this recall is…
Complaints by component
ELECTRICAL SYSTEM
4
1fires
ENGINE
4
1fires
BACK OVER PREVENTION: SENSING SYSTEM: CAMERA
2
BACK OVER PREVENTION: WARNINGS
2
FUEL/PROPULSION SYSTEM
2
POWER TRAIN
2
BACK OVER PREVENTION: REARVIEW SYSTEM BRAKING
1
FUEL SYSTEM, GASOLINE
1
SERVICE BRAKES
1
Total complaints19
What owners report
Verbatim reports filed with NHTSA, lightly edited for readability and with personal
information removed.
“Vehicle: 2021 mercedes-benz e350 sedan (w213) vin: [xxx] while operating the vehicle, the diagnostic system displayed the fault code p240200 related to the evaporative emission control system (evap). The warning message indicated a “positive short circuitâ€� in the fuel vapor leak diagnosis pump…”
“Vehicle: 2021 mercedes-benz e350 sedan (w213) vin: [xxx] while operating the vehicle, the diagnostic system displayed the fault code p240200 related to the evaporative emission control system (evap). The warning message indicated a “positive short circuitâ€� in the fuel vapor leak diagnosis pump…”
“With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .”
“Engine keeps having a misfire that mercedes put a tsb out for and once the misfire happen I cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the freeway. The car had 54k miles and mercedes refused to repair the issue as the engine part failure…”
“The mercedes e350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded.”
“My 2021 mercedes-benz e350 (vin [xxx] ) developed a serious engine issue involving cylinder misfire and check engine light. The dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to tsb li01.30-p-072328, which documents valve seat wear in m260 engines. This is a known defect…”
“1) rear view camera sometimes working, some times not working. (message reads “system inoperative “ 2) forward view camera also affected. 3) display shown “12v battery low in battery “ 4) not long ago, just had vehicle suddenly vibrating vigorously while backing up from parking and during…”
“1) rear view camera sometimes working, some times not working. (message reads “system inoperative “ 2) forward view camera also affected. 3) display shown “12v battery low in battery “ 4) not long ago, just had vehicle suddenly vibrating vigorously while backing up from parking and during…”
Recall, complaint, and investigation records from official NHTSA datasets (FLAT_RCL,
FLAT_CMPL, FLAT_INV), synced weekly. Counts reflect NHTSA records for the 2021 Mercedes-Benz E 350 as of
July 5, 2026. Complaint narratives are consumer-submitted and unverified. This page
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